| Rancho Santa Margarita to Des Plaines (Illinois) | 1,711.08 mi (2,753.71 km) |
| Rancho Santa Margarita to Desert Hot Springs (California) | 64.61 mi (103.98 km) |
| Rancho Santa Margarita to DeSoto (Texas) | 1,200.09 mi (1,931.36 km) |
| Rancho Santa Margarita to Destin (Florida) | 1,830.45 mi (2,945.83 km) |
| Rancho Santa Margarita to Destrehan (Louisiana) | 1,614.31 mi (2,597.98 km) |
| Rancho Santa Margarita to Detroit (Michigan) | 1,957.53 mi (3,150.34 km) |
| Rancho Santa Margarita to Diamond Bar (California) | 28.28 mi (45.52 km) |
| Rancho Santa Margarita to Diamond Springs (California) | 393.51 mi (633.30 km) |
| Rancho Santa Margarita to Dickinson (North Dakota) | 1,199.50 mi (1,930.40 km) |
| Rancho Santa Margarita to Dickinson (Texas) | 1,355.34 mi (2,181.20 km) |
| Rancho Santa Margarita to Dickson (Tennessee) | 1,715.58 mi (2,760.97 km) |
| Rancho Santa Margarita to Difficult Run (Virginia) | 2,253.23 mi (3,626.23 km) |
| Rancho Santa Margarita to Dinuba (California) | 225.55 mi (362.99 km) |
| Rancho Santa Margarita to Discovery Bay (California) | 370.74 mi (596.65 km) |
| Rancho Santa Margarita to Dix Hills (New York) | 2,458.44 mi (3,956.48 km) |
