| Rancho Santa Margarita to Delaware (Ohio) | 1,947.59 mi (3,134.34 km) |
| Rancho Santa Margarita to Delhi (California) | 317.45 mi (510.88 km) |
| Rancho Santa Margarita to Delray Beach (Florida) | 2,284.51 mi (3,676.57 km) |
| Rancho Santa Margarita to Deltona (Florida) | 2,162.30 mi (3,479.89 km) |
| Rancho Santa Margarita to Deming (New Mexico) | 578.44 mi (930.91 km) |
| Rancho Santa Margarita to Denison (Texas) | 1,206.11 mi (1,941.04 km) |
| Rancho Santa Margarita to Dent (Ohio) | 1,860.65 mi (2,994.42 km) |
| Rancho Santa Margarita to Denton (Texas) | 1,178.10 mi (1,895.97 km) |
| Rancho Santa Margarita to Dentsville (South Carolina) | 2,091.41 mi (3,365.80 km) |
| Rancho Santa Margarita to Denver (Colorado) | 821.11 mi (1,321.44 km) |
| Rancho Santa Margarita to Depew (New York) | 2,183.40 mi (3,513.85 km) |
| Rancho Santa Margarita to Derby (Connecticut) | 2,470.02 mi (3,975.11 km) |
| Rancho Santa Margarita to Derby (Kansas) | 1,172.17 mi (1,886.43 km) |
| Rancho Santa Margarita to Des Moines (Iowa) | 1,417.10 mi (2,280.60 km) |
| Rancho Santa Margarita to Des Moines (Washington) | 981.97 mi (1,580.32 km) |
