| Rancho Santa Margarita to Decatur (Alabama) | 1,745.65 mi (2,809.35 km) |
| Rancho Santa Margarita to Decatur (Georgia) | 1,905.82 mi (3,067.12 km) |
| Rancho Santa Margarita to Decatur (Illinois) | 1,636.44 mi (2,633.59 km) |
| Rancho Santa Margarita to Deer Park (New York) | 2,459.41 mi (3,958.04 km) |
| Rancho Santa Margarita to Deer Park (Texas) | 1,347.17 mi (2,168.06 km) |
| Rancho Santa Margarita to Deerfield (Illinois) | 1,715.15 mi (2,760.27 km) |
| Rancho Santa Margarita to Deerfield Beach (Florida) | 2,286.23 mi (3,679.32 km) |
| Rancho Santa Margarita to Defiance (Ohio) | 1,884.95 mi (3,033.53 km) |
| Rancho Santa Margarita to DeForest (Wisconsin) | 1,656.59 mi (2,666.02 km) |
| Rancho Santa Margarita to DeKalb (Illinois) | 1,666.99 mi (2,682.76 km) |
| Rancho Santa Margarita to Del Aire (California) | 48.43 mi (77.94 km) |
| Rancho Santa Margarita to Del City (Oklahoma) | 1,152.10 mi (1,854.13 km) |
| Rancho Santa Margarita to Del Rio (Texas) | 1,026.59 mi (1,652.14 km) |
| Rancho Santa Margarita to DeLand (Florida) | 2,155.56 mi (3,469.03 km) |
| Rancho Santa Margarita to Delano (California) | 175.18 mi (281.92 km) |
