| Rancho Santa Margarita to Darby (Pennsylvania) | 2,360.47 mi (3,798.82 km) |
| Rancho Santa Margarita to Dardenne Prairie (Missouri) | 1,533.37 mi (2,467.72 km) |
| Rancho Santa Margarita to Darien (Illinois) | 1,703.56 mi (2,741.61 km) |
| Rancho Santa Margarita to Davenport (Iowa) | 1,568.05 mi (2,523.53 km) |
| Rancho Santa Margarita to Davidson (North Carolina) | 2,084.36 mi (3,354.46 km) |
| Rancho Santa Margarita to Davie (Florida) | 2,282.94 mi (3,674.04 km) |
| Rancho Santa Margarita to Davis (California) | 411.11 mi (661.61 km) |
| Rancho Santa Margarita to Dayton (Nevada) | 403.85 mi (649.94 km) |
| Rancho Santa Margarita to Dayton (Ohio) | 1,886.56 mi (3,036.12 km) |
| Rancho Santa Margarita to Daytona Beach (Florida) | 2,162.72 mi (3,480.56 km) |
| Rancho Santa Margarita to De Pere (Wisconsin) | 1,738.57 mi (2,797.96 km) |
| Rancho Santa Margarita to De Witt (New York) | 2,316.22 mi (3,727.60 km) |
| Rancho Santa Margarita to Dearborn (Michigan) | 1,951.37 mi (3,140.43 km) |
| Rancho Santa Margarita to Dearborn Heights (Michigan) | 1,948.16 mi (3,135.25 km) |
| Rancho Santa Margarita to DeBary (Florida) | 2,156.46 mi (3,470.49 km) |
