| Rancho Santa Margarita to Crawfordsville (Indiana) | 1,745.05 mi (2,808.39 km) |
| Rancho Santa Margarita to Crest Hill (Illinois) | 1,694.99 mi (2,727.82 km) |
| Rancho Santa Margarita to Crestview (Florida) | 1,817.96 mi (2,925.73 km) |
| Rancho Santa Margarita to Crestwood (Illinois) | 1,714.80 mi (2,759.71 km) |
| Rancho Santa Margarita to Crestwood (Missouri) | 1,551.27 mi (2,496.53 km) |
| Rancho Santa Margarita to Creve Coeur (Missouri) | 1,548.35 mi (2,491.83 km) |
| Rancho Santa Margarita to Crofton (Maryland) | 2,288.53 mi (3,683.04 km) |
| Rancho Santa Margarita to Crossville (Tennessee) | 1,846.42 mi (2,971.52 km) |
| Rancho Santa Margarita to Crowley (Louisiana) | 1,494.06 mi (2,404.45 km) |
| Rancho Santa Margarita to Crowley (Texas) | 1,171.85 mi (1,885.91 km) |
| Rancho Santa Margarita to Crown Point (Indiana) | 1,732.56 mi (2,788.28 km) |
| Rancho Santa Margarita to Crystal (Minnesota) | 1,507.34 mi (2,425.83 km) |
| Rancho Santa Margarita to Crystal Lake (Illinois) | 1,691.68 mi (2,722.50 km) |
| Rancho Santa Margarita to Cudahy (California) | 40.61 mi (65.35 km) |
| Rancho Santa Margarita to Cudahy (Wisconsin) | 1,724.91 mi (2,775.97 km) |
