| Rancho Santa Margarita to Conyers (Georgia) | 1,924.00 mi (3,096.38 km) |
| Rancho Santa Margarita to Cookeville (Tennessee) | 1,818.58 mi (2,926.73 km) |
| Rancho Santa Margarita to Coolidge (Arizona) | 354.02 mi (569.74 km) |
| Rancho Santa Margarita to Coon Rapids (Minnesota) | 1,513.36 mi (2,435.51 km) |
| Rancho Santa Margarita to Cooper City (Florida) | 2,283.84 mi (3,675.49 km) |
| Rancho Santa Margarita to Coos Bay (Oregon) | 762.40 mi (1,226.97 km) |
| Rancho Santa Margarita to Copiague (New York) | 2,456.06 mi (3,952.65 km) |
| Rancho Santa Margarita to Coppell (Texas) | 1,189.07 mi (1,913.63 km) |
| Rancho Santa Margarita to Copperas Cove (Texas) | 1,159.90 mi (1,866.68 km) |
| Rancho Santa Margarita to Coral Gables (Florida) | 2,293.75 mi (3,691.44 km) |
| Rancho Santa Margarita to Coral Springs (Florida) | 2,279.57 mi (3,668.62 km) |
| Rancho Santa Margarita to Coral Terrace (Florida) | 2,290.70 mi (3,686.52 km) |
| Rancho Santa Margarita to Coralville (Iowa) | 1,520.12 mi (2,446.40 km) |
| Rancho Santa Margarita to Coram (New York) | 2,475.48 mi (3,983.89 km) |
| Rancho Santa Margarita to Corcoran (California) | 202.69 mi (326.20 km) |
