| Rancho Santa Margarita to Colton (California) | 33.11 mi (53.28 km) |
| Rancho Santa Margarita to Columbia (Illinois) | 1,559.56 mi (2,509.87 km) |
| Rancho Santa Margarita to Columbia (Maryland) | 2,278.19 mi (3,666.39 km) |
| Rancho Santa Margarita to Columbia (Missouri) | 1,449.37 mi (2,332.54 km) |
| Rancho Santa Margarita to Columbia (Pennsylvania) | 2,294.88 mi (3,693.26 km) |
| Rancho Santa Margarita to Columbia (South Carolina) | 2,094.73 mi (3,371.14 km) |
| Rancho Santa Margarita to Columbia (Tennessee) | 1,735.40 mi (2,792.86 km) |
| Rancho Santa Margarita to Columbia Heights (Minnesota) | 1,512.69 mi (2,434.44 km) |
| Rancho Santa Margarita to Columbine (Colorado) | 806.48 mi (1,297.90 km) |
| Rancho Santa Margarita to Columbus (Georgia) | 1,888.27 mi (3,038.88 km) |
| Rancho Santa Margarita to Columbus (Indiana) | 1,793.37 mi (2,886.14 km) |
| Rancho Santa Margarita to Columbus (Mississippi) | 1,674.76 mi (2,695.27 km) |
| Rancho Santa Margarita to Columbus (Nebraska) | 1,229.15 mi (1,978.12 km) |
| Rancho Santa Margarita to Columbus (Ohio) | 1,951.45 mi (3,140.56 km) |
| Rancho Santa Margarita to Commack (New York) | 2,461.13 mi (3,960.81 km) |
