| Rancho Santa Margarita to Cloverleaf (Texas) | 1,341.86 mi (2,159.52 km) |
| Rancho Santa Margarita to Cloverly (Maryland) | 2,271.04 mi (3,654.89 km) |
| Rancho Santa Margarita to Clovis (California) | 250.18 mi (402.62 km) |
| Rancho Santa Margarita to Clovis (New Mexico) | 826.06 mi (1,329.41 km) |
| Rancho Santa Margarita to Clute (Texas) | 1,345.50 mi (2,165.37 km) |
| Rancho Santa Margarita to Coachella (California) | 83.82 mi (134.89 km) |
| Rancho Santa Margarita to Coalinga (California) | 232.23 mi (373.73 km) |
| Rancho Santa Margarita to Coamo (Puerto Rico) | 3,325.45 mi (5,351.79 km) |
| Rancho Santa Margarita to Coatesville (Pennsylvania) | 2,330.69 mi (3,750.88 km) |
| Rancho Santa Margarita to Cockeysville (Maryland) | 2,289.41 mi (3,684.45 km) |
| Rancho Santa Margarita to Cocoa (Florida) | 2,199.40 mi (3,539.60 km) |
| Rancho Santa Margarita to Cocoa Beach (Florida) | 2,208.57 mi (3,554.34 km) |
| Rancho Santa Margarita to Coconut Creek (Florida) | 2,283.62 mi (3,675.12 km) |
| Rancho Santa Margarita to Coeur d'Alene (Idaho) | 973.20 mi (1,566.21 km) |
| Rancho Santa Margarita to Cohoes (New York) | 2,436.02 mi (3,920.39 km) |
