| Rancho Santa Margarita to Clarksdale (Mississippi) | 1,545.80 mi (2,487.73 km) |
| Rancho Santa Margarita to Clarkston (Georgia) | 1,908.55 mi (3,071.51 km) |
| Rancho Santa Margarita to Clarksville (Indiana) | 1,799.90 mi (2,896.65 km) |
| Rancho Santa Margarita to Clarksville (Tennessee) | 1,715.30 mi (2,760.51 km) |
| Rancho Santa Margarita to Clawson (Michigan) | 1,956.32 mi (3,148.40 km) |
| Rancho Santa Margarita to Clay (Alabama) | 1,775.33 mi (2,857.11 km) |
| Rancho Santa Margarita to Clayton (California) | 384.03 mi (618.03 km) |
| Rancho Santa Margarita to Clayton (Missouri) | 1,554.32 mi (2,501.43 km) |
| Rancho Santa Margarita to Clayton (North Carolina) | 2,215.04 mi (3,564.77 km) |
| Rancho Santa Margarita to Clayton (Ohio) | 1,879.99 mi (3,025.55 km) |
| Rancho Santa Margarita to Clearfield (Utah) | 599.83 mi (965.34 km) |
| Rancho Santa Margarita to Clearlake (California) | 462.49 mi (744.31 km) |
| Rancho Santa Margarita to Clearwater (Florida) | 2,093.80 mi (3,369.64 km) |
| Rancho Santa Margarita to Cleburne (Texas) | 1,171.11 mi (1,884.71 km) |
| Rancho Santa Margarita to Clemmons (North Carolina) | 2,104.21 mi (3,386.40 km) |
