| Rancho Santa Margarita to Channelview (Texas) | 1,345.12 mi (2,164.76 km) |
| Rancho Santa Margarita to Chantilly (Virginia) | 2,248.02 mi (3,617.84 km) |
| Rancho Santa Margarita to Chaparral (New Mexico) | 658.62 mi (1,059.95 km) |
| Rancho Santa Margarita to Chapel Hill (North Carolina) | 2,179.85 mi (3,508.13 km) |
| Rancho Santa Margarita to Charleston (Illinois) | 1,674.04 mi (2,694.11 km) |
| Rancho Santa Margarita to Charleston (South Carolina) | 2,163.58 mi (3,481.95 km) |
| Rancho Santa Margarita to Charleston (West Virginia) | 2,023.95 mi (3,257.23 km) |
| Rancho Santa Margarita to Charlotte (North Carolina) | 2,086.55 mi (3,357.97 km) |
| Rancho Santa Margarita to Charlottesville (Virginia) | 2,195.71 mi (3,533.66 km) |
| Rancho Santa Margarita to Chaska (Minnesota) | 1,490.14 mi (2,398.15 km) |
| Rancho Santa Margarita to Chatham (Illinois) | 1,594.98 mi (2,566.88 km) |
| Rancho Santa Margarita to Chattanooga (Tennessee) | 1,840.02 mi (2,961.23 km) |
| Rancho Santa Margarita to Cheat Lake (West Virginia) | 2,117.24 mi (3,407.36 km) |
| Rancho Santa Margarita to Chelsea (Alabama) | 1,778.11 mi (2,861.59 km) |
| Rancho Santa Margarita to Chelsea (Massachusetts) | 2,572.56 mi (4,140.13 km) |
