| Rancho Santa Margarita to Central Point (Oregon) | 669.49 mi (1,077.44 km) |
| Rancho Santa Margarita to Centralia (Illinois) | 1,618.80 mi (2,605.21 km) |
| Rancho Santa Margarita to Centralia (Washington) | 947.27 mi (1,524.49 km) |
| Rancho Santa Margarita to Centreville (Virginia) | 2,248.56 mi (3,618.71 km) |
| Rancho Santa Margarita to Ceres (California) | 332.62 mi (535.31 km) |
| Rancho Santa Margarita to Cerritos (California) | 31.53 mi (50.75 km) |
| Rancho Santa Margarita to Chalco (Nebraska) | 1,283.83 mi (2,066.13 km) |
| Rancho Santa Margarita to Chalmette (Louisiana) | 1,637.77 mi (2,635.73 km) |
| Rancho Santa Margarita to Chambersburg (Pennsylvania) | 2,233.67 mi (3,594.75 km) |
| Rancho Santa Margarita to Chamblee (Georgia) | 1,904.34 mi (3,064.74 km) |
| Rancho Santa Margarita to Champaign (Illinois) | 1,673.12 mi (2,692.63 km) |
| Rancho Santa Margarita to Champlin (Minnesota) | 1,509.60 mi (2,429.46 km) |
| Rancho Santa Margarita to Chandler (Arizona) | 332.14 mi (534.53 km) |
| Rancho Santa Margarita to Chanhassen (Minnesota) | 1,493.29 mi (2,403.22 km) |
| Rancho Santa Margarita to Channahon (Illinois) | 1,685.80 mi (2,713.03 km) |
