| Rancho Santa Margarita to Castle Pines (Colorado) | 812.15 mi (1,307.02 km) |
| Rancho Santa Margarita to Castle Rock (Colorado) | 810.40 mi (1,304.21 km) |
| Rancho Santa Margarita to Castro Valley (California) | 376.90 mi (606.56 km) |
| Rancho Santa Margarita to Catalina Foothills (Arizona) | 399.82 mi (643.45 km) |
| Rancho Santa Margarita to Cataño (Puerto Rico) | 3,325.88 mi (5,352.49 km) |
| Rancho Santa Margarita to Cathedral City (California) | 66.71 mi (107.35 km) |
| Rancho Santa Margarita to Catonsville (Maryland) | 2,284.17 mi (3,676.02 km) |
| Rancho Santa Margarita to Cave Spring (Virginia) | 2,117.03 mi (3,407.02 km) |
| Rancho Santa Margarita to Cayce (South Carolina) | 2,087.94 mi (3,360.22 km) |
| Rancho Santa Margarita to Cayey (Puerto Rico) | 3,335.65 mi (5,368.20 km) |
| Rancho Santa Margarita to Cedar City (Utah) | 377.09 mi (606.87 km) |
| Rancho Santa Margarita to Cedar Falls (Iowa) | 1,491.76 mi (2,400.76 km) |
| Rancho Santa Margarita to Cedar Hill (Texas) | 1,194.78 mi (1,922.81 km) |
| Rancho Santa Margarita to Cedar Lake (Indiana) | 1,727.34 mi (2,779.88 km) |
| Rancho Santa Margarita to Cedar Mill (Oregon) | 867.36 mi (1,395.88 km) |
