| Rancho Santa Margarita to Carrollwood (Florida) | 2,106.22 mi (3,389.64 km) |
| Rancho Santa Margarita to Carson (California) | 40.34 mi (64.92 km) |
| Rancho Santa Margarita to Carson City (Nevada) | 399.60 mi (643.09 km) |
| Rancho Santa Margarita to Carteret (New Jersey) | 2,412.57 mi (3,882.65 km) |
| Rancho Santa Margarita to Cartersville (Georgia) | 1,873.13 mi (3,014.51 km) |
| Rancho Santa Margarita to Carthage (Missouri) | 1,329.90 mi (2,140.26 km) |
| Rancho Santa Margarita to Cary (Illinois) | 1,695.72 mi (2,729.01 km) |
| Rancho Santa Margarita to Cary (North Carolina) | 2,193.34 mi (3,529.85 km) |
| Rancho Santa Margarita to Casa de Oro-Mount Helix (California) | 70.16 mi (112.90 km) |
| Rancho Santa Margarita to Casa Grande (Arizona) | 340.81 mi (548.49 km) |
| Rancho Santa Margarita to Casas Adobes (Arizona) | 391.96 mi (630.80 km) |
| Rancho Santa Margarita to Cascades (Virginia) | 2,250.50 mi (3,621.83 km) |
| Rancho Santa Margarita to Casper (Wyoming) | 881.36 mi (1,418.41 km) |
| Rancho Santa Margarita to Casselberry (Florida) | 2,161.33 mi (3,478.33 km) |
| Rancho Santa Margarita to Castaic (California) | 83.33 mi (134.11 km) |
