| Rancho Santa Margarita to Blue Island (Illinois) | 1,717.92 mi (2,764.73 km) |
| Rancho Santa Margarita to Blue Springs (Missouri) | 1,346.47 mi (2,166.93 km) |
| Rancho Santa Margarita to Bluffdale (Utah) | 566.22 mi (911.25 km) |
| Rancho Santa Margarita to Bluffton (Indiana) | 1,839.65 mi (2,960.63 km) |
| Rancho Santa Margarita to Bluffton (South Carolina) | 2,117.72 mi (3,408.14 km) |
| Rancho Santa Margarita to Blythe (California) | 171.40 mi (275.84 km) |
| Rancho Santa Margarita to Blytheville (Arkansas) | 1,574.30 mi (2,533.59 km) |
| Rancho Santa Margarita to Boca Raton (Florida) | 2,285.55 mi (3,678.24 km) |
| Rancho Santa Margarita to Boerne (Texas) | 1,138.77 mi (1,832.67 km) |
| Rancho Santa Margarita to Bogalusa (Louisiana) | 1,628.49 mi (2,620.80 km) |
| Rancho Santa Margarita to Boiling Springs (South Carolina) | 2,023.79 mi (3,256.97 km) |
| Rancho Santa Margarita to Boise (Idaho) | 692.69 mi (1,114.78 km) |
| Rancho Santa Margarita to Bolingbrook (Illinois) | 1,696.84 mi (2,730.80 km) |
| Rancho Santa Margarita to Bolivar (Missouri) | 1,381.59 mi (2,223.45 km) |
| Rancho Santa Margarita to Bon Air (Virginia) | 2,248.46 mi (3,618.55 km) |
