| Rancho Santa Margarita to Anoka (Minnesota) | 1,510.73 mi (2,431.29 km) |
| Rancho Santa Margarita to Ansonia (Connecticut) | 2,470.71 mi (3,976.23 km) |
| Rancho Santa Margarita to Antelope (California) | 409.04 mi (658.29 km) |
| Rancho Santa Margarita to Anthem (Arizona) | 315.30 mi (507.43 km) |
| Rancho Santa Margarita to Antioch (California) | 381.37 mi (613.76 km) |
| Rancho Santa Margarita to Antioch (Illinois) | 1,708.04 mi (2,748.82 km) |
| Rancho Santa Margarita to Apache Junction (Arizona) | 349.63 mi (562.68 km) |
| Rancho Santa Margarita to Apex (North Carolina) | 2,190.83 mi (3,525.81 km) |
| Rancho Santa Margarita to Apollo Beach (Florida) | 2,119.67 mi (3,411.28 km) |
| Rancho Santa Margarita to Apopka (Florida) | 2,148.41 mi (3,457.53 km) |
| Rancho Santa Margarita to Apple Valley (California) | 66.25 mi (106.62 km) |
| Rancho Santa Margarita to Apple Valley (Minnesota) | 1,506.77 mi (2,424.92 km) |
| Rancho Santa Margarita to Appleton (Wisconsin) | 1,720.98 mi (2,769.66 km) |
| Rancho Santa Margarita to Arbutus (Maryland) | 2,286.94 mi (3,680.47 km) |
| Rancho Santa Margarita to Arcadia (California) | 42.87 mi (68.99 km) |
