| Rancho Santa Margarita to Altus (Oklahoma) | 1,047.00 mi (1,684.98 km) |
| Rancho Santa Margarita to Alum Rock (California) | 350.87 mi (564.67 km) |
| Rancho Santa Margarita to Alvin (Texas) | 1,343.36 mi (2,161.93 km) |
| Rancho Santa Margarita to Amarillo (Texas) | 904.25 mi (1,455.24 km) |
| Rancho Santa Margarita to Amelia (Ohio) | 1,883.89 mi (3,031.83 km) |
| Rancho Santa Margarita to American Canyon (California) | 408.20 mi (656.94 km) |
| Rancho Santa Margarita to American Fork (Utah) | 565.22 mi (909.63 km) |
| Rancho Santa Margarita to Americus (Georgia) | 1,931.75 mi (3,108.85 km) |
| Rancho Santa Margarita to Ames (Iowa) | 1,424.93 mi (2,293.21 km) |
| Rancho Santa Margarita to Amherst (Ohio) | 1,996.03 mi (3,212.30 km) |
| Rancho Santa Margarita to Ammon (Idaho) | 744.80 mi (1,198.64 km) |
| Rancho Santa Margarita to Amsterdam (New York) | 2,411.64 mi (3,881.15 km) |
| Rancho Santa Margarita to Anacortes (Washington) | 1,058.77 mi (1,703.93 km) |
| Rancho Santa Margarita to Anaheim (California) | 20.63 mi (33.21 km) |
| Rancho Santa Margarita to Anchorage (Alaska) | 2,359.19 mi (3,796.75 km) |
