| Rancho Santa Margarita to Abilene (Texas) | 1,036.35 mi (1,667.84 km) |
| Rancho Santa Margarita to Accokeek (Maryland) | 2,272.77 mi (3,657.67 km) |
| Rancho Santa Margarita to Acworth (Georgia) | 1,881.53 mi (3,028.03 km) |
| Rancho Santa Margarita to Ada (Oklahoma) | 1,196.52 mi (1,925.61 km) |
| Rancho Santa Margarita to Addison (Illinois) | 1,704.39 mi (2,742.96 km) |
| Rancho Santa Margarita to Addison (Texas) | 1,198.01 mi (1,928.01 km) |
| Rancho Santa Margarita to Adelanto (California) | 66.24 mi (106.60 km) |
| Rancho Santa Margarita to Adelphi (Maryland) | 2,273.32 mi (3,658.55 km) |
| Rancho Santa Margarita to Adrian (Michigan) | 1,905.83 mi (3,067.13 km) |
| Rancho Santa Margarita to Affton (Missouri) | 1,554.03 mi (2,500.98 km) |
| Rancho Santa Margarita to Agoura Hills (California) | 75.69 mi (121.81 km) |
| Rancho Santa Margarita to Aguadilla (Puerto Rico) | 3,268.01 mi (5,259.36 km) |
| Rancho Santa Margarita to Aiken (South Carolina) | 2,054.27 mi (3,306.02 km) |
| Rancho Santa Margarita to Akron (Ohio) | 2,031.43 mi (3,269.28 km) |
| Rancho Santa Margarita to Alabaster (Alabama) | 1,768.34 mi (2,845.88 km) |
