| Rancho Santa Margarita to Sestu | 6,353.73 mi (10,225.34 km) |
| Rancho Santa Margarita to Settimo Torinese | 6,010.16 mi (9,672.42 km) |
| Rancho Santa Margarita to Seveso | 6,028.96 mi (9,702.67 km) |
| Rancho Santa Margarita to Sezze | 6,374.27 mi (10,258.39 km) |
| Rancho Santa Margarita to Siano | 6,464.79 mi (10,404.08 km) |
| Rancho Santa Margarita to Siena | 6,221.08 mi (10,011.87 km) |
| Rancho Santa Margarita to Signa | 6,189.12 mi (9,960.42 km) |
| Rancho Santa Margarita to Silea | 6,128.10 mi (9,862.23 km) |
| Rancho Santa Margarita to Silvi Paese | 6,351.54 mi (10,221.82 km) |
| Rancho Santa Margarita to Sinalunga | 6,239.50 mi (10,041.51 km) |
| Rancho Santa Margarita to Siniscola | 6,309.27 mi (10,153.79 km) |
| Rancho Santa Margarita to Sinnai | 6,357.54 mi (10,231.47 km) |
| Rancho Santa Margarita to Siracusa | 6,687.69 mi (10,762.80 km) |
| Rancho Santa Margarita to Solaro | 6,028.69 mi (9,702.24 km) |
| Rancho Santa Margarita to Soliera | 6,133.37 mi (9,870.71 km) |
