| Pueblo West to Southern Pines (North Carolina) | 1,413.71 mi (2,275.15 km) |
| Pueblo West to Southfield (Michigan) | 1,161.22 mi (1,868.80 km) |
| Pueblo West to Southgate (Michigan) | 1,161.86 mi (1,869.84 km) |
| Pueblo West to Southlake (Texas) | 564.98 mi (909.25 km) |
| Pueblo West to Spanaway (Washington) | 1,078.96 mi (1,736.41 km) |
| Pueblo West to Spanish Fork (Utah) | 389.57 mi (626.95 km) |
| Pueblo West to Spanish Lake (Missouri) | 784.01 mi (1,261.74 km) |
| Pueblo West to Spanish Springs (Nevada) | 806.59 mi (1,298.08 km) |
| Pueblo West to Sparks (Nevada) | 808.93 mi (1,301.85 km) |
| Pueblo West to Spartanburg (South Carolina) | 1,282.17 mi (2,063.45 km) |
| Pueblo West to Spearfish (South Dakota) | 427.13 mi (687.41 km) |
| Pueblo West to Speedway (Indiana) | 994.37 mi (1,600.28 km) |
| Pueblo West to Spencer (Iowa) | 600.24 mi (965.99 km) |
| Pueblo West to Spokane (Washington) | 907.17 mi (1,459.94 km) |
| Pueblo West to Spokane Valley (Washington) | 899.98 mi (1,448.37 km) |
