| Prudhoe to Southern Pines (North Carolina) | 3,802.97 mi (6,120.29 km) |
| Prudhoe to Southfield (Michigan) | 3,590.46 mi (5,778.29 km) |
| Prudhoe to Southgate (Michigan) | 3,601.48 mi (5,796.02 km) |
| Prudhoe to Southlake (Texas) | 4,585.53 mi (7,379.70 km) |
| Prudhoe to Spanaway (Washington) | 4,585.18 mi (7,379.13 km) |
| Prudhoe to Spanish Fork (Utah) | 4,680.36 mi (7,532.31 km) |
| Prudhoe to Spanish Lake (Missouri) | 4,026.95 mi (6,480.75 km) |
| Prudhoe to Spanish Springs (Nevada) | 4,944.64 mi (7,957.63 km) |
| Prudhoe to Sparks (Nevada) | 4,950.82 mi (7,967.58 km) |
| Prudhoe to Spartanburg (South Carolina) | 3,912.60 mi (6,296.72 km) |
| Prudhoe to Spearfish (South Dakota) | 4,196.31 mi (6,753.31 km) |
| Prudhoe to Speedway (Indiana) | 3,831.43 mi (6,166.09 km) |
| Prudhoe to Spencer (Iowa) | 3,979.99 mi (6,405.17 km) |
| Prudhoe to Spokane (Washington) | 4,422.29 mi (7,116.98 km) |
| Prudhoe to Spokane Valley (Washington) | 4,417.22 mi (7,108.82 km) |
