| Prospect Heights to Enterprise (Nevada) | 1,516.77 mi (2,441.00 km) |
| Prospect Heights to Enumclaw (Washington) | 1,696.66 mi (2,730.51 km) |
| Prospect Heights to Ephrata (Pennsylvania) | 624.87 mi (1,005.64 km) |
| Prospect Heights to Erie (Colorado) | 901.15 mi (1,450.26 km) |
| Prospect Heights to Erie (Pennsylvania) | 402.40 mi (647.60 km) |
| Prospect Heights to Erlanger (Kentucky) | 276.38 mi (444.80 km) |
| Prospect Heights to Escanaba (Michigan) | 255.18 mi (410.67 km) |
| Prospect Heights to Escondido (California) | 1,700.91 mi (2,737.34 km) |
| Prospect Heights to Española (New Mexico) | 1,057.96 mi (1,702.62 km) |
| Prospect Heights to Essex (Maryland) | 631.21 mi (1,015.83 km) |
| Prospect Heights to Essex Junction (Vermont) | 761.76 mi (1,225.93 km) |
| Prospect Heights to Estelle (Louisiana) | 855.63 mi (1,377.01 km) |
| Prospect Heights to Estero (Florida) | 1,137.49 mi (1,830.61 km) |
| Prospect Heights to Euclid (Ohio) | 331.64 mi (533.72 km) |
| Prospect Heights to Eufaula (Alabama) | 720.66 mi (1,159.80 km) |
