| Prestwick to Southern Pines (North Carolina) | 3,688.73 mi (5,936.44 km) |
| Prestwick to Southfield (Michigan) | 3,475.52 mi (5,593.31 km) |
| Prestwick to Southgate (Michigan) | 3,486.51 mi (5,611.00 km) |
| Prestwick to Southlake (Texas) | 4,470.83 mi (7,195.10 km) |
| Prestwick to Spanaway (Washington) | 4,486.11 mi (7,219.70 km) |
| Prestwick to Spanish Fork (Utah) | 4,571.73 mi (7,357.49 km) |
| Prestwick to Spanish Lake (Missouri) | 3,912.16 mi (6,296.02 km) |
| Prestwick to Spanish Springs (Nevada) | 4,839.86 mi (7,789.01 km) |
| Prestwick to Sparks (Nevada) | 4,846.04 mi (7,798.94 km) |
| Prestwick to Spartanburg (South Carolina) | 3,798.02 mi (6,112.32 km) |
| Prestwick to Spearfish (South Dakota) | 4,086.39 mi (6,576.40 km) |
| Prestwick to Speedway (Indiana) | 3,716.46 mi (5,981.06 km) |
| Prestwick to Spencer (Iowa) | 3,866.92 mi (6,223.20 km) |
| Prestwick to Spokane (Washington) | 4,320.54 mi (6,953.24 km) |
| Prestwick to Spokane Valley (Washington) | 4,315.35 mi (6,944.89 km) |
