| Prestwick to Sesena | 1,064.31 mi (1,712.84 km) |
| Prestwick to Sestao | 844.93 mi (1,359.78 km) |
| Prestwick to Sevilla | 1,262.98 mi (2,032.57 km) |
| Prestwick to Sevilla La Nueva | 1,046.97 mi (1,684.94 km) |
| Prestwick to Silla | 1,131.40 mi (1,820.82 km) |
| Prestwick to Silleda | 898.81 mi (1,446.49 km) |
| Prestwick to Sitges | 1,027.42 mi (1,653.47 km) |
| Prestwick to Socuellamos | 1,122.60 mi (1,806.66 km) |
| Prestwick to Soller | 1,137.36 mi (1,830.40 km) |
| Prestwick to Solsona | 972.85 mi (1,565.64 km) |
| Prestwick to Son Servera | 1,156.33 mi (1,860.94 km) |
| Prestwick to Sonseca | 1,091.80 mi (1,757.08 km) |
| Prestwick to Sopelana | 840.17 mi (1,352.12 km) |
| Prestwick to Soria | 953.51 mi (1,534.53 km) |
| Prestwick to Suances | 833.80 mi (1,341.87 km) |
