| Prestwick to Sestu | 1,284.38 mi (2,067.00 km) |
| Prestwick to Settimo Torinese | 897.75 mi (1,444.79 km) |
| Prestwick to Seveso | 906.44 mi (1,458.78 km) |
| Prestwick to Sezze | 1,253.67 mi (2,017.59 km) |
| Prestwick to Siano | 1,340.93 mi (2,158.02 km) |
| Prestwick to Siena | 1,100.02 mi (1,770.31 km) |
| Prestwick to Signa | 1,067.04 mi (1,717.23 km) |
| Prestwick to Silea | 1,001.59 mi (1,611.90 km) |
| Prestwick to Silvi Paese | 1,225.30 mi (1,971.92 km) |
| Prestwick to Sinalunga | 1,117.31 mi (1,798.14 km) |
| Prestwick to Siniscola | 1,219.46 mi (1,962.53 km) |
| Prestwick to Sinnai | 1,286.69 mi (2,070.73 km) |
| Prestwick to Siracusa | 1,576.62 mi (2,537.32 km) |
| Prestwick to Solaro | 906.49 mi (1,458.86 km) |
| Prestwick to Soliera | 1,008.61 mi (1,623.20 km) |
