| Prestwick to Savignano sul Rubicone | 1,088.28 mi (1,751.42 km) |
| Prestwick to Savona | 964.69 mi (1,552.51 km) |
| Prestwick to Scafati | 1,338.76 mi (2,154.52 km) |
| Prestwick to Scalea | 1,430.00 mi (2,301.36 km) |
| Prestwick to Scandiano | 1,009.73 mi (1,625.00 km) |
| Prestwick to Scandicci | 1,071.24 mi (1,723.99 km) |
| Prestwick to Schio | 969.06 mi (1,559.56 km) |
| Prestwick to Sciacca | 1,491.62 mi (2,400.53 km) |
| Prestwick to Scicli | 1,577.51 mi (2,538.76 km) |
| Prestwick to Scordia | 1,550.83 mi (2,495.82 km) |
| Prestwick to Scorze | 999.96 mi (1,609.28 km) |
| Prestwick to Sedico | 971.44 mi (1,563.39 km) |
| Prestwick to Sedriano | 910.53 mi (1,465.35 km) |
| Prestwick to Segni | 1,241.70 mi (1,998.32 km) |
| Prestwick to Segrate | 919.51 mi (1,479.80 km) |
