| Prestonpans to Southern Pines (North Carolina) | 3,745.60 mi (6,027.96 km) |
| Prestonpans to Southfield (Michigan) | 3,524.68 mi (5,672.42 km) |
| Prestonpans to Southgate (Michigan) | 3,535.94 mi (5,690.54 km) |
| Prestonpans to Southlake (Texas) | 4,517.98 mi (7,270.99 km) |
| Prestonpans to Spanaway (Washington) | 4,504.37 mi (7,249.09 km) |
| Prestonpans to Spanish Fork (Utah) | 4,603.35 mi (7,408.38 km) |
| Prestonpans to Spanish Lake (Missouri) | 3,959.89 mi (6,372.83 km) |
| Prestonpans to Spanish Springs (Nevada) | 4,865.50 mi (7,830.26 km) |
| Prestonpans to Sparks (Nevada) | 4,871.69 mi (7,840.23 km) |
| Prestonpans to Spartanburg (South Carolina) | 3,853.58 mi (6,201.74 km) |
| Prestonpans to Spearfish (South Dakota) | 4,120.36 mi (6,631.07 km) |
| Prestonpans to Speedway (Indiana) | 3,765.94 mi (6,060.69 km) |
| Prestonpans to Spencer (Iowa) | 3,907.93 mi (6,289.21 km) |
| Prestonpans to Spokane (Washington) | 4,342.12 mi (6,987.97 km) |
| Prestonpans to Spokane Valley (Washington) | 4,337.08 mi (6,979.86 km) |
