| Preston to Sestu | 1,142.11 mi (1,838.05 km) |
| Preston to Settimo Torinese | 757.45 mi (1,219.00 km) |
| Preston to Seveso | 768.90 mi (1,237.42 km) |
| Preston to Sezze | 1,115.80 mi (1,795.70 km) |
| Preston to Siano | 1,204.37 mi (1,938.24 km) |
| Preston to Siena | 962.13 mi (1,548.39 km) |
| Preston to Signa | 929.48 mi (1,495.86 km) |
| Preston to Silea | 870.14 mi (1,400.35 km) |
| Preston to Silvi Paese | 1,090.45 mi (1,754.91 km) |
| Preston to Sinalunga | 979.85 mi (1,576.92 km) |
| Preston to Siniscola | 1,077.71 mi (1,734.40 km) |
| Preston to Sinnai | 1,144.45 mi (1,841.81 km) |
| Preston to Siracusa | 1,437.19 mi (2,312.94 km) |
| Preston to Solaro | 768.80 mi (1,237.27 km) |
| Preston to Soliera | 872.40 mi (1,403.99 km) |
