| Preston to Sacile | 861.90 mi (1,387.09 km) |
| Preston to Sala Consilina | 1,254.93 mi (2,019.61 km) |
| Preston to Salemi | 1,324.43 mi (2,131.47 km) |
| Preston to Salerno | 1,213.19 mi (1,952.44 km) |
| Preston to Salo | 814.74 mi (1,311.20 km) |
| Preston to Salsomaggiore Terme | 839.21 mi (1,350.58 km) |
| Preston to Saluzzo | 778.18 mi (1,252.36 km) |
| Preston to Salzano | 870.08 mi (1,400.26 km) |
| Preston to Samarate | 759.69 mi (1,222.60 km) |
| Preston to San Benedetto del Tronto | 1,061.56 mi (1,708.41 km) |
| Preston to San Biagio di Callalta | 871.45 mi (1,402.46 km) |
| Preston to San Bonifacio | 849.26 mi (1,366.75 km) |
| Preston to San Casciano in Val di Pesa | 939.03 mi (1,511.22 km) |
| Preston to San Cataldo | 1,376.22 mi (2,214.81 km) |
| Preston to San Cesareo | 1,089.98 mi (1,754.16 km) |
