| Prescott to Southern Pines (North Carolina) | 1,864.50 mi (3,000.63 km) |
| Prescott to Southfield (Michigan) | 1,659.33 mi (2,670.43 km) |
| Prescott to Southgate (Michigan) | 1,659.12 mi (2,670.09 km) |
| Prescott to Southlake (Texas) | 884.92 mi (1,424.13 km) |
| Prescott to Spanaway (Washington) | 1,007.76 mi (1,621.83 km) |
| Prescott to Spanish Fork (Utah) | 384.31 mi (618.49 km) |
| Prescott to Spanish Lake (Missouri) | 1,262.56 mi (2,031.90 km) |
| Prescott to Spanish Springs (Nevada) | 529.87 mi (852.74 km) |
| Prescott to Sparks (Nevada) | 528.20 mi (850.06 km) |
| Prescott to Spartanburg (South Carolina) | 1,725.84 mi (2,777.47 km) |
| Prescott to Spearfish (South Dakota) | 823.55 mi (1,325.38 km) |
| Prescott to Speedway (Indiana) | 1,480.48 mi (2,382.59 km) |
| Prescott to Spencer (Iowa) | 1,099.17 mi (1,768.94 km) |
| Prescott to Spokane (Washington) | 939.88 mi (1,512.59 km) |
| Prescott to Spokane Valley (Washington) | 936.82 mi (1,507.67 km) |
