| Portsmouth to Southern Pines (North Carolina) | 3,907.08 mi (6,287.84 km) |
| Portsmouth to Southfield (Michigan) | 3,735.73 mi (6,012.08 km) |
| Portsmouth to Southgate (Michigan) | 3,745.50 mi (6,027.79 km) |
| Portsmouth to Southlake (Texas) | 4,736.83 mi (7,623.20 km) |
| Portsmouth to Spanaway (Washington) | 4,828.27 mi (7,770.36 km) |
| Portsmouth to Spanish Fork (Utah) | 4,888.64 mi (7,867.50 km) |
| Portsmouth to Spanish Lake (Missouri) | 4,177.24 mi (6,722.62 km) |
| Portsmouth to Spanish Springs (Nevada) | 5,169.62 mi (8,319.71 km) |
| Portsmouth to Sparks (Nevada) | 5,175.76 mi (8,329.58 km) |
| Portsmouth to Spartanburg (South Carolina) | 4,023.86 mi (6,475.78 km) |
| Portsmouth to Spearfish (South Dakota) | 4,398.04 mi (7,077.96 km) |
| Portsmouth to Speedway (Indiana) | 3,974.34 mi (6,396.08 km) |
| Portsmouth to Spencer (Iowa) | 4,157.88 mi (6,691.46 km) |
| Portsmouth to Spokane (Washington) | 4,657.92 mi (7,496.20 km) |
| Portsmouth to Spokane Valley (Washington) | 4,652.50 mi (7,487.48 km) |
