| Port Lavaca to Southern Pines (North Carolina) | 1,105.62 mi (1,779.33 km) |
| Port Lavaca to Southfield (Michigan) | 1,213.95 mi (1,953.67 km) |
| Port Lavaca to Southgate (Michigan) | 1,202.03 mi (1,934.47 km) |
| Port Lavaca to Southlake (Texas) | 301.22 mi (484.76 km) |
| Port Lavaca to Spanaway (Washington) | 1,883.91 mi (3,031.86 km) |
| Port Lavaca to Spanish Fork (Utah) | 1,164.62 mi (1,874.28 km) |
| Port Lavaca to Spanish Lake (Missouri) | 793.15 mi (1,276.45 km) |
| Port Lavaca to Spanish Springs (Nevada) | 1,515.85 mi (2,439.52 km) |
| Port Lavaca to Sparks (Nevada) | 1,515.89 mi (2,439.59 km) |
| Port Lavaca to Spartanburg (South Carolina) | 966.43 mi (1,555.32 km) |
| Port Lavaca to Spearfish (South Dakota) | 1,165.81 mi (1,876.20 km) |
| Port Lavaca to Speedway (Indiana) | 972.13 mi (1,564.50 km) |
| Port Lavaca to Spencer (Iowa) | 1,007.18 mi (1,620.89 km) |
| Port Lavaca to Spokane (Washington) | 1,723.73 mi (2,774.08 km) |
| Port Lavaca to Spokane Valley (Washington) | 1,716.71 mi (2,762.78 km) |
