| Port Huron to Superior (Colorado) | 1,191.36 mi (1,917.31 km) |
| Port Huron to Superior (Wisconsin) | 537.07 mi (864.32 km) |
| Port Huron to Surprise (Arizona) | 1,737.42 mi (2,796.11 km) |
| Port Huron to Susanville (California) | 1,960.25 mi (3,154.72 km) |
| Port Huron to Sussex (Wisconsin) | 292.12 mi (470.12 km) |
| Port Huron to Suwanee (Georgia) | 623.31 mi (1,003.13 km) |
| Port Huron to Swansea (Illinois) | 499.37 mi (803.66 km) |
| Port Huron to Sweetwater (Florida) | 1,194.35 mi (1,922.13 km) |
| Port Huron to Sweetwater (Texas) | 1,217.18 mi (1,958.86 km) |
| Port Huron to Sycamore (Illinois) | 325.23 mi (523.41 km) |
| Port Huron to Sylacauga (Alabama) | 708.35 mi (1,139.98 km) |
| Port Huron to Sylvania (Ohio) | 109.24 mi (175.80 km) |
| Port Huron to Syosset (New York) | 483.07 mi (777.43 km) |
| Port Huron to Syracuse (New York) | 317.99 mi (511.76 km) |
| Port Huron to Syracuse (Utah) | 1,518.35 mi (2,443.56 km) |
