| Port Huron to Storm Lake (Iowa) | 646.41 mi (1,040.29 km) |
| Port Huron to Storrs (Connecticut) | 525.77 mi (846.15 km) |
| Port Huron to Stoughton (Wisconsin) | 342.98 mi (551.98 km) |
| Port Huron to Stow (Ohio) | 134.97 mi (217.21 km) |
| Port Huron to Streamwood (Illinois) | 299.73 mi (482.37 km) |
| Port Huron to Streator (Illinois) | 351.98 mi (566.46 km) |
| Port Huron to Streetsboro (Ohio) | 132.79 mi (213.71 km) |
| Port Huron to Strongsville (Ohio) | 119.46 mi (192.25 km) |
| Port Huron to Stuart (Florida) | 1,097.64 mi (1,766.49 km) |
| Port Huron to Stuarts Draft (Virginia) | 386.66 mi (622.27 km) |
| Port Huron to Sturgis (Michigan) | 172.61 mi (277.79 km) |
| Port Huron to Suamico (Wisconsin) | 302.97 mi (487.58 km) |
| Port Huron to Sudley (Virginia) | 387.98 mi (624.40 km) |
| Port Huron to Suffern (New York) | 444.60 mi (715.51 km) |
| Port Huron to Suffolk (Virginia) | 531.99 mi (856.15 km) |
