| Port Huron to Stephenville (Texas) | 1,136.65 mi (1,829.26 km) |
| Port Huron to Sterling (Colorado) | 1,078.49 mi (1,735.66 km) |
| Port Huron to Sterling (Illinois) | 379.09 mi (610.08 km) |
| Port Huron to Sterling (Virginia) | 379.88 mi (611.35 km) |
| Port Huron to Sterling Heights (Michigan) | 40.85 mi (65.74 km) |
| Port Huron to Steubenville (Ohio) | 202.95 mi (326.62 km) |
| Port Huron to Stevens Point (Wisconsin) | 370.44 mi (596.17 km) |
| Port Huron to Stevenson Ranch (California) | 2,020.53 mi (3,251.73 km) |
| Port Huron to Stillwater (Minnesota) | 535.46 mi (861.73 km) |
| Port Huron to Stillwater (Oklahoma) | 910.11 mi (1,464.68 km) |
| Port Huron to Stockbridge (Georgia) | 660.53 mi (1,063.02 km) |
| Port Huron to Stockton (California) | 2,053.26 mi (3,304.40 km) |
| Port Huron to Stone Ridge (Virginia) | 378.45 mi (609.06 km) |
| Port Huron to Stonecrest (Georgia) | 648.94 mi (1,044.37 km) |
| Port Huron to Stony Brook (New York) | 499.23 mi (803.43 km) |
