| Port Huron to St. George (Utah) | 1,686.61 mi (2,714.34 km) |
| Port Huron to St. Helens (Oregon) | 1,981.10 mi (3,188.27 km) |
| Port Huron to St. James (New York) | 498.74 mi (802.65 km) |
| Port Huron to St. John (Indiana) | 278.49 mi (448.19 km) |
| Port Huron to St. Joseph (Missouri) | 678.75 mi (1,092.34 km) |
| Port Huron to St. Louis (Missouri) | 506.43 mi (815.01 km) |
| Port Huron to St. Louis Park (Minnesota) | 559.61 mi (900.61 km) |
| Port Huron to St. Marys (Georgia) | 846.04 mi (1,361.56 km) |
| Port Huron to St. Marys (Pennsylvania) | 225.83 mi (363.44 km) |
| Port Huron to St. Matthews (Kentucky) | 367.45 mi (591.36 km) |
| Port Huron to St. Michael (Minnesota) | 578.56 mi (931.10 km) |
| Port Huron to St. Paul (Minnesota) | 547.04 mi (880.38 km) |
| Port Huron to St. Peter (Minnesota) | 583.19 mi (938.55 km) |
| Port Huron to St. Peters (Missouri) | 515.58 mi (829.75 km) |
| Port Huron to St. Petersburg (Florida) | 1,049.53 mi (1,689.06 km) |
