| Port Huron to Southern Pines (North Carolina) | 562.16 mi (904.70 km) |
| Port Huron to Southfield (Michigan) | 54.40 mi (87.55 km) |
| Port Huron to Southgate (Michigan) | 66.38 mi (106.83 km) |
| Port Huron to Southlake (Texas) | 1,056.49 mi (1,700.26 km) |
| Port Huron to Spanaway (Washington) | 1,951.01 mi (3,139.86 km) |
| Port Huron to Spanish Fork (Utah) | 1,515.28 mi (2,438.61 km) |
| Port Huron to Spanish Lake (Missouri) | 498.30 mi (801.93 km) |
| Port Huron to Spanish Springs (Nevada) | 1,929.64 mi (3,105.46 km) |
| Port Huron to Sparks (Nevada) | 1,933.88 mi (3,112.28 km) |
| Port Huron to Spartanburg (South Carolina) | 556.05 mi (894.87 km) |
| Port Huron to Spearfish (South Dakota) | 1,069.16 mi (1,720.65 km) |
| Port Huron to Speedway (Indiana) | 295.78 mi (476.00 km) |
| Port Huron to Spencer (Iowa) | 641.30 mi (1,032.07 km) |
| Port Huron to Spokane (Washington) | 1,715.28 mi (2,760.48 km) |
| Port Huron to Spokane Valley (Washington) | 1,706.07 mi (2,745.65 km) |
