| Port Huron to Seymour (Tennessee) | 495.90 mi (798.07 km) |
| Port Huron to Shady Hills (Florida) | 1,007.25 mi (1,621.02 km) |
| Port Huron to Shafter (California) | 2,017.21 mi (3,246.38 km) |
| Port Huron to Shaker Heights (Ohio) | 113.67 mi (182.93 km) |
| Port Huron to Shakopee (Minnesota) | 563.04 mi (906.13 km) |
| Port Huron to Sharon (Pennsylvania) | 156.41 mi (251.72 km) |
| Port Huron to Sharonville (Ohio) | 275.35 mi (443.14 km) |
| Port Huron to Shasta Lake (California) | 2,042.92 mi (3,287.76 km) |
| Port Huron to Shawnee (Kansas) | 699.91 mi (1,126.39 km) |
| Port Huron to Shawnee (Oklahoma) | 937.74 mi (1,509.14 km) |
| Port Huron to Sheboygan (Wisconsin) | 270.94 mi (436.03 km) |
| Port Huron to Shelby (North Carolina) | 533.59 mi (858.73 km) |
| Port Huron to Shelbyville (Indiana) | 294.60 mi (474.11 km) |
| Port Huron to Shelbyville (Kentucky) | 360.91 mi (580.83 km) |
| Port Huron to Shelbyville (Tennessee) | 559.69 mi (900.73 km) |
