| Port Huron to Scottsboro (Alabama) | 607.86 mi (978.26 km) |
| Port Huron to Scottsdale (Arizona) | 1,708.22 mi (2,749.11 km) |
| Port Huron to Scranton (Pennsylvania) | 363.36 mi (584.78 km) |
| Port Huron to Seabrook (Maryland) | 401.61 mi (646.32 km) |
| Port Huron to Seabrook (Texas) | 1,158.82 mi (1,864.94 km) |
| Port Huron to Seaford (New York) | 487.30 mi (784.24 km) |
| Port Huron to Seagoville (Texas) | 1,047.15 mi (1,685.23 km) |
| Port Huron to Seal Beach (California) | 2,015.46 mi (3,243.57 km) |
| Port Huron to Searcy (Arkansas) | 730.10 mi (1,174.99 km) |
| Port Huron to Seaside (California) | 2,115.90 mi (3,405.21 km) |
| Port Huron to SeaTac (Washington) | 1,942.64 mi (3,126.38 km) |
| Port Huron to Seattle (Washington) | 1,942.65 mi (3,126.39 km) |
| Port Huron to Sebastian (Florida) | 1,055.90 mi (1,699.30 km) |
| Port Huron to Sebring (Florida) | 1,072.72 mi (1,726.38 km) |
| Port Huron to Secaucus (New Jersey) | 456.53 mi (734.72 km) |
