| Port Huron to Santa Rosa (California) | 2,111.52 mi (3,398.17 km) |
| Port Huron to Santaquin (Utah) | 1,525.90 mi (2,455.70 km) |
| Port Huron to Santee (California) | 1,991.94 mi (3,205.71 km) |
| Port Huron to Sapulpa (Oklahoma) | 871.59 mi (1,402.69 km) |
| Port Huron to Saraland (Alabama) | 894.26 mi (1,439.17 km) |
| Port Huron to Sarasota (Florida) | 1,080.87 mi (1,739.49 km) |
| Port Huron to Sarasota Springs (Florida) | 1,082.93 mi (1,742.81 km) |
| Port Huron to Saratoga (California) | 2,108.29 mi (3,392.96 km) |
| Port Huron to Saratoga Springs (New York) | 437.34 mi (703.83 km) |
| Port Huron to Saratoga Springs (Utah) | 1,524.45 mi (2,453.37 km) |
| Port Huron to Sartell (Minnesota) | 609.75 mi (981.30 km) |
| Port Huron to Satellite Beach (Florida) | 1,027.97 mi (1,654.36 km) |
| Port Huron to Sauk Rapids (Minnesota) | 606.28 mi (975.72 km) |
| Port Huron to Sault Ste. Marie (Michigan) | 259.73 mi (418.00 km) |
| Port Huron to Savage (Minnesota) | 557.31 mi (896.90 km) |
