| Port Huron to Sanford (Maine) | 588.64 mi (947.32 km) |
| Port Huron to Sanford (North Carolina) | 546.34 mi (879.24 km) |
| Port Huron to Sanger (California) | 1,999.38 mi (3,217.70 km) |
| Port Huron to Santa Ana (California) | 2,006.53 mi (3,229.20 km) |
| Port Huron to Santa Barbara (California) | 2,076.32 mi (3,341.51 km) |
| Port Huron to Santa Clara (California) | 2,102.72 mi (3,384.00 km) |
| Port Huron to Santa Clara (Oregon) | 2,018.53 mi (3,248.51 km) |
| Port Huron to Santa Clarita (California) | 2,015.00 mi (3,242.82 km) |
| Port Huron to Santa Cruz (California) | 2,116.70 mi (3,406.50 km) |
| Port Huron to Santa Fe (New Mexico) | 1,350.49 mi (2,173.41 km) |
| Port Huron to Santa Fe (Texas) | 1,172.10 mi (1,886.31 km) |
| Port Huron to Santa Fe Springs (California) | 2,009.05 mi (3,233.26 km) |
| Port Huron to Santa Maria (California) | 2,096.78 mi (3,374.45 km) |
| Port Huron to Santa Monica (California) | 2,027.10 mi (3,262.29 km) |
| Port Huron to Santa Paula (California) | 2,045.71 mi (3,292.25 km) |
