| Port Huron to San Luis Obispo (California) | 2,097.85 mi (3,376.16 km) |
| Port Huron to San Marcos (California) | 1,991.61 mi (3,205.19 km) |
| Port Huron to San Marcos (Texas) | 1,245.94 mi (2,005.15 km) |
| Port Huron to San Marino (California) | 2,005.33 mi (3,227.27 km) |
| Port Huron to San Mateo (California) | 2,115.01 mi (3,403.77 km) |
| Port Huron to San Pablo (California) | 2,105.64 mi (3,388.70 km) |
| Port Huron to San Rafael (California) | 2,113.96 mi (3,402.10 km) |
| Port Huron to San Ramon (California) | 2,090.44 mi (3,364.25 km) |
| Port Huron to San Tan Valley (Arizona) | 1,711.57 mi (2,754.51 km) |
| Port Huron to Sand Springs (Oklahoma) | 867.53 mi (1,396.15 km) |
| Port Huron to Sandusky (Ohio) | 106.93 mi (172.09 km) |
| Port Huron to Sandy (Oregon) | 1,960.12 mi (3,154.51 km) |
| Port Huron to Sandy (Utah) | 1,516.79 mi (2,441.04 km) |
| Port Huron to Sandy Springs (Georgia) | 633.61 mi (1,019.69 km) |
| Port Huron to Sanford (Florida) | 982.77 mi (1,581.62 km) |
