| Port Huron to Salisbury (New York) | 481.99 mi (775.69 km) |
| Port Huron to Salisbury (North Carolina) | 516.08 mi (830.55 km) |
| Port Huron to Salmon Creek (Washington) | 1,975.41 mi (3,179.12 km) |
| Port Huron to Salt Lake City (Utah) | 1,516.96 mi (2,441.31 km) |
| Port Huron to Sammamish (Washington) | 1,929.66 mi (3,105.48 km) |
| Port Huron to San Angelo (Texas) | 1,267.26 mi (2,039.45 km) |
| Port Huron to San Anselmo (California) | 2,116.59 mi (3,406.33 km) |
| Port Huron to San Antonio (Texas) | 1,290.23 mi (2,076.42 km) |
| Port Huron to San Benito (Texas) | 1,445.62 mi (2,326.51 km) |
| Port Huron to San Bernardino (California) | 1,963.54 mi (3,160.01 km) |
| Port Huron to San Bruno (California) | 2,119.05 mi (3,410.28 km) |
| Port Huron to San Buenaventura (California) | 2,056.67 mi (3,309.89 km) |
| Port Huron to San Carlos (California) | 2,114.22 mi (3,402.51 km) |
| Port Huron to San Carlos Park (Florida) | 1,140.96 mi (1,836.20 km) |
| Port Huron to San Clemente (California) | 2,002.61 mi (3,222.88 km) |
