| Port Huron to Enterprise (Nevada) | 1,800.74 mi (2,898.02 km) |
| Port Huron to Enumclaw (Washington) | 1,929.98 mi (3,106.00 km) |
| Port Huron to Ephrata (Pennsylvania) | 376.74 mi (606.30 km) |
| Port Huron to Erie (Colorado) | 1,183.16 mi (1,904.10 km) |
| Port Huron to Erie (Pennsylvania) | 134.43 mi (216.34 km) |
| Port Huron to Erlanger (Kentucky) | 296.33 mi (476.90 km) |
| Port Huron to Escanaba (Michigan) | 298.73 mi (480.77 km) |
| Port Huron to Escondido (California) | 1,986.52 mi (3,196.99 km) |
| Port Huron to Española (New Mexico) | 1,343.39 mi (2,161.98 km) |
| Port Huron to Essex (Maryland) | 402.21 mi (647.29 km) |
| Port Huron to Essex Junction (Vermont) | 476.74 mi (767.24 km) |
| Port Huron to Estelle (Louisiana) | 1,001.65 mi (1,612.00 km) |
| Port Huron to Estero (Florida) | 1,144.38 mi (1,841.70 km) |
| Port Huron to Euclid (Ohio) | 107.04 mi (172.27 km) |
| Port Huron to Eufaula (Alabama) | 779.20 mi (1,254.00 km) |
