| Port Huron to Des Plaines (Illinois) | 285.75 mi (459.86 km) |
| Port Huron to Desert Hot Springs (California) | 1,932.03 mi (3,109.30 km) |
| Port Huron to DeSoto (Texas) | 1,062.52 mi (1,709.96 km) |
| Port Huron to Destin (Florida) | 897.61 mi (1,444.56 km) |
| Port Huron to Destrehan (Louisiana) | 1,000.48 mi (1,610.11 km) |
| Port Huron to Detroit (Michigan) | 53.36 mi (85.87 km) |
| Port Huron to Diamond Bar (California) | 1,994.47 mi (3,209.78 km) |
| Port Huron to Diamond Springs (California) | 2,011.32 mi (3,236.91 km) |
| Port Huron to Dickinson (North Dakota) | 1,028.22 mi (1,654.76 km) |
| Port Huron to Dickinson (Texas) | 1,166.93 mi (1,877.99 km) |
| Port Huron to Dickson (Tennessee) | 545.16 mi (877.35 km) |
| Port Huron to Difficult Run (Virginia) | 387.28 mi (623.27 km) |
| Port Huron to Dinuba (California) | 1,995.72 mi (3,211.81 km) |
| Port Huron to Discovery Bay (California) | 2,069.63 mi (3,330.74 km) |
| Port Huron to Dix Hills (New York) | 491.42 mi (790.86 km) |
