| Port Charlotte to Enterprise (Nevada) | 2,036.51 mi (3,277.44 km) |
| Port Charlotte to Enumclaw (Washington) | 2,563.01 mi (4,124.77 km) |
| Port Charlotte to Ephrata (Pennsylvania) | 972.54 mi (1,565.15 km) |
| Port Charlotte to Erie (Colorado) | 1,591.30 mi (2,560.95 km) |
| Port Charlotte to Erie (Pennsylvania) | 1,051.37 mi (1,692.02 km) |
| Port Charlotte to Erlanger (Kentucky) | 842.60 mi (1,356.04 km) |
| Port Charlotte to Escanaba (Michigan) | 1,324.46 mi (2,131.51 km) |
| Port Charlotte to Escondido (California) | 2,122.92 mi (3,416.51 km) |
| Port Charlotte to Española (New Mexico) | 1,537.07 mi (2,473.67 km) |
| Port Charlotte to Essex (Maryland) | 911.06 mi (1,466.21 km) |
| Port Charlotte to Essex Junction (Vermont) | 1,308.13 mi (2,105.24 km) |
| Port Charlotte to Estelle (Louisiana) | 523.74 mi (842.88 km) |
| Port Charlotte to Estero (Florida) | 43.67 mi (70.28 km) |
| Port Charlotte to Euclid (Ohio) | 1,009.22 mi (1,624.19 km) |
| Port Charlotte to Eufaula (Alabama) | 385.77 mi (620.83 km) |
