| Port Charlotte to Elyria (Ohio) | 993.85 mi (1,599.45 km) |
| Port Charlotte to Emeryville (California) | 2,439.40 mi (3,925.83 km) |
| Port Charlotte to Emmaus (Pennsylvania) | 1,009.18 mi (1,624.12 km) |
| Port Charlotte to Emporia (Kansas) | 1,133.93 mi (1,824.89 km) |
| Port Charlotte to Encinitas (California) | 2,133.63 mi (3,433.74 km) |
| Port Charlotte to Endicott (New York) | 1,098.29 mi (1,767.52 km) |
| Port Charlotte to Endwell (New York) | 1,100.35 mi (1,770.84 km) |
| Port Charlotte to Englewood (Colorado) | 1,576.76 mi (2,537.55 km) |
| Port Charlotte to Englewood (Florida) | 14.74 mi (23.73 km) |
| Port Charlotte to Englewood (New Jersey) | 1,066.50 mi (1,716.37 km) |
| Port Charlotte to Englewood (Ohio) | 898.26 mi (1,445.61 km) |
| Port Charlotte to Enid (Oklahoma) | 1,129.33 mi (1,817.48 km) |
| Port Charlotte to Ennis (Texas) | 945.42 mi (1,521.51 km) |
| Port Charlotte to Ensley (Florida) | 396.50 mi (638.10 km) |
| Port Charlotte to Enterprise (Alabama) | 374.70 mi (603.03 km) |
