| Port Charlotte to Effingham (Illinois) | 916.51 mi (1,474.98 km) |
| Port Charlotte to Eggertsville (New York) | 1,119.26 mi (1,801.28 km) |
| Port Charlotte to Egypt Lake-Leto (Florida) | 74.85 mi (120.45 km) |
| Port Charlotte to El Cajon (California) | 2,115.68 mi (3,404.85 km) |
| Port Charlotte to El Campo (Texas) | 875.77 mi (1,409.42 km) |
| Port Charlotte to El Centro (California) | 2,034.32 mi (3,273.93 km) |
| Port Charlotte to El Cerrito (California) | 2,440.48 mi (3,927.58 km) |
| Port Charlotte to El Dorado (Arkansas) | 762.68 mi (1,227.41 km) |
| Port Charlotte to El Dorado (Kansas) | 1,137.47 mi (1,830.57 km) |
| Port Charlotte to El Dorado Hills (California) | 2,379.37 mi (3,829.23 km) |
| Port Charlotte to El Mirage (Arizona) | 1,852.06 mi (2,980.61 km) |
| Port Charlotte to El Monte (California) | 2,180.90 mi (3,509.83 km) |
| Port Charlotte to El Paso (Texas) | 1,497.93 mi (2,410.68 km) |
| Port Charlotte to El Paso de Robles (California) | 2,336.16 mi (3,759.68 km) |
| Port Charlotte to El Reno (Oklahoma) | 1,104.79 mi (1,777.99 km) |
