| Ponce to Enterprise (Nevada) | 3,201.31 mi (5,152.01 km) |
| Ponce to Enumclaw (Washington) | 3,700.13 mi (5,954.79 km) |
| Ponce to Ephrata (Pennsylvania) | 1,634.30 mi (2,630.15 km) |
| Ponce to Erie (Colorado) | 2,743.19 mi (4,414.74 km) |
| Ponce to Erie (Pennsylvania) | 1,844.08 mi (2,967.76 km) |
| Ponce to Erlanger (Kentucky) | 1,807.50 mi (2,908.90 km) |
| Ponce to Escanaba (Michigan) | 2,246.87 mi (3,615.98 km) |
| Ponce to Escondido (California) | 3,279.25 mi (5,277.45 km) |
| Ponce to Española (New Mexico) | 2,702.74 mi (4,349.65 km) |
| Ponce to Essex (Maryland) | 1,584.44 mi (2,549.92 km) |
| Ponce to Essex Junction (Vermont) | 1,867.68 mi (3,005.75 km) |
| Ponce to Estelle (Louisiana) | 1,688.13 mi (2,716.78 km) |
| Ponce to Estero (Florida) | 1,129.90 mi (1,818.41 km) |
| Ponce to Euclid (Ohio) | 1,851.47 mi (2,979.66 km) |
| Ponce to Eufaula (Alabama) | 1,502.04 mi (2,417.30 km) |
