| Point Pleasant to Southern Pines (North Carolina) | 445.98 mi (717.74 km) |
| Point Pleasant to Southfield (Michigan) | 504.87 mi (812.51 km) |
| Point Pleasant to Southgate (Michigan) | 497.27 mi (800.28 km) |
| Point Pleasant to Southlake (Texas) | 1,367.93 mi (2,201.47 km) |
| Point Pleasant to Spanaway (Washington) | 2,427.84 mi (3,907.23 km) |
| Point Pleasant to Spanish Fork (Utah) | 1,970.71 mi (3,171.55 km) |
| Point Pleasant to Spanish Lake (Missouri) | 864.58 mi (1,391.40 km) |
| Point Pleasant to Spanish Springs (Nevada) | 2,391.22 mi (3,848.29 km) |
| Point Pleasant to Sparks (Nevada) | 2,395.17 mi (3,854.66 km) |
| Point Pleasant to Spartanburg (South Carolina) | 557.37 mi (897.01 km) |
| Point Pleasant to Spearfish (South Dakota) | 1,541.79 mi (2,481.27 km) |
| Point Pleasant to Speedway (Indiana) | 644.96 mi (1,037.96 km) |
| Point Pleasant to Spencer (Iowa) | 1,106.47 mi (1,780.69 km) |
| Point Pleasant to Spokane (Washington) | 2,192.05 mi (3,527.77 km) |
| Point Pleasant to Spokane Valley (Washington) | 2,182.84 mi (3,512.94 km) |
