| Pittsburgh to Superior (Colorado) | 1,325.16 mi (2,132.65 km) |
| Pittsburgh to Superior (Wisconsin) | 743.00 mi (1,195.74 km) |
| Pittsburgh to Surprise (Arizona) | 1,839.12 mi (2,959.77 km) |
| Pittsburgh to Susanville (California) | 2,117.89 mi (3,408.42 km) |
| Pittsburgh to Sussex (Wisconsin) | 463.57 mi (746.05 km) |
| Pittsburgh to Suwanee (Georgia) | 495.35 mi (797.19 km) |
| Pittsburgh to Swansea (Illinois) | 549.07 mi (883.65 km) |
| Pittsburgh to Sweetwater (Florida) | 1,013.25 mi (1,630.67 km) |
| Pittsburgh to Sweetwater (Texas) | 1,257.92 mi (2,024.43 km) |
| Pittsburgh to Sycamore (Illinois) | 464.83 mi (748.08 km) |
| Pittsburgh to Sylacauga (Alabama) | 610.01 mi (981.71 km) |
| Pittsburgh to Sylvania (Ohio) | 213.30 mi (343.27 km) |
| Pittsburgh to Syosset (New York) | 340.42 mi (547.85 km) |
| Pittsburgh to Syracuse (New York) | 267.04 mi (429.76 km) |
| Pittsburgh to Syracuse (Utah) | 1,670.59 mi (2,688.55 km) |
